Publications

1. Deenadayalu, VP, RE White, JN Stallone, X Gao, AJ Garcia. (2001). Testosterone Relaxes Coronary Arteries by Opening the Large-Conductance, Calcium Activated Potassium Channel. Am J Physiol Heart Circ Physiol 281: H1720-H1727. PMID 11557563
2. Stunden, CE, JA Filosa, AJ Garcia 3rd, JB Dean, RW Putnam (2001). Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in Rats. Res Physiol. 127: 135-155. PMID 11504586
3. Dean, JB, DK Mulkey, AJ Garcia 3rd, RA Henderson 3rd, RW Putnam (2003). Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures. J Appl Physiol. 95: 883-909. PMID 12909594
4. Ramirez, JM and AJ Garcia (2007). Point: Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals. J Appl Physiol. 103: 717-718. PMID 17272416
5. Ramirez, JM and AJ Garcia (2007). Last Word on Point: Counterpoint Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals. J Appl Physiol. 103: 726. PMID 17666732
6. Hill*,AA, AJ Garcia 3rd*, S Zanella, R Upadhyaya, JM Ramirez. (2010). Response of the brainstem respiratory central pattern generator to graded reductions in oxygenation. J Neurophysiol. 105: 625-39. PMID 21084689; PMC3059168
7. Garcia, AJ 3rd, RW Putnam, and JB Dean. (2010). Hyperbaric hyperoxia and normobaric reoxygenation increase excitability and activate oxygen-induced potentiation (OxIP) in CA1 hippocampal neurons. J Appl Physiol. 109(3):804-19. PMID 20558753, PMC2944633
8. Garcia, AJ 3rd, RW Putnam, and JB Dean. (2010). Hyperoxic stimulation of synchronous orthodromic activity and induction of neural plasticity does not require changes in excitatory synaptic transmission. J Appl Physiol. 109(3):820-9. PMID 20558752; PMCID 2944636
9. Garcia, AJ 3rd, S Khan, G Kumar, N Prabhakar, JM Ramirez. (2011). Hydrogen peroxide but not hydroxyl radical modulates neuronal activity in the preBötzinger complex. J Neurophysiol. 106: 3045-3055.PMID 21849609; PMC3234088
10. Viemari, JC, AJ Garcia 3rd, A Doi and JM Ramirez. (2011). Activation of alpha-2 noradrenergic receptors is critical for the generation of inspiratory activities in mammals in vitro. Eur J Neurosci. 33: 2228-37. PMID21615559; PMC3652413
11. Koch H, AJ Garcia 3rd, Ramirez JM. (2011) Network reconfiguration and neuronal plasticity in rhythm-generating networks. Integr Comp Biol. 51:856-68. PMID 21856733; PMC3223481
12. Garcia, AJ 3rd*, S Zanella*, H Koch*, A Doi and JM Ramirez (2011). Chapter 3--networks within networks: the neuronal control of breathing. Prog in Brain Res. 188:31-50. PMID 21333801; PMC3652403
13. Ramirez, JM, H Koch, AJ Garcia 3rd, A Doi, and S Zanella. (2011). The role of spiking and bursting pacemakers in the neuronal control of breathing. J Biol Phys. 37: 241-261. PMID 22654176; PMC3101325
14. Ramirez JM, A Doi, AJ Garcia 3rd, FP Elsen, H Koch, A. Wei. (2012) Cellular properties of respiratory brainstem neurons: The building blocks of breathing. Comprehensive Physiol. 2: 2683-2731. PMID23720262; PMC3684023
15. Madisen L, T Mao, H Koch, J Zhuo, A Berenyi, S Fujisawa, YWA Hsu, AJ Garcia 3rd, Xuan Gu, S Zanella, J Kidney, H Gu, Y Mao, BM Hooks, ES Boyden, G Buzsáki, JM Ramirez, AR. Jones, K Svoboda, X Han, E Turner, H Zeng. (2012) A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing of targeted neural activity. Nat. Neurosci. 15:793-802. PMID22446880; PMC3337962
16. Hodge, RD, AJ Garcia 3rd, GE Elsen, BR Nelson, KE, Mussar, SL Reiner, JM Ramirez, RF Hevner. (2013) Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J. Neurosci. 33:4165-4180.PMID23447624; PMC3623668
17. Koch H, S Zanella, G Elsen, L Smith, A Doi, AJ Garcia 3rd, A Wei, R Xun, S Kirsch, C Gomez, R Hevner, JM Ramirez. (2013) Stable respiratory activity requires both P/Q-type and N-type voltage gated channels. J. Neurosci. 33:3633-3645. PMID23426690; PMC3652398
18. Garcia, AJ 3rd*, N Kohavi-Rotem*, A Doi, JM Ramirez. (2013) Neonatal gender influences recovery from hypoxia in vivo and in the in vitro preBötzinger complex. PLoS One. 8(4):e60695. doi: 10.1371/journal.pone.0060695. PMID23593283; PMC3620234
19. Garcia, AJ 3rd, JE Koschnitzky, T Deshevskiy, JM Ramirez. Cardio-respiratory coupling in health and disease. (2013) Autonomic Neurosci. 175:26-37. PMID23497744; PMC3683976
20. Ramirez JM, Garcia, AJ 3rd, TM Anderson, JE Koschnitzky, YJ Peng, G Kumar, NR Prabhakar. (2013) Central and peripheral factors contributing to obstructive and central sleep apnea. Respir. Physiol. Neurobiol. 189:344-53. PMID23770311
21. Garcia, AJ 3rd*, JE Koschnitzky*, JM Ramirez. (2013) The physiological determinants of Sudden Infant Death Syndrome. Respir. Physiol. Neurobiol. 189:288-300.
22. Allen T, Garica AJ 3rd, Tang J, Ramirez JM, Rubens DD. (2013) Inner ear insult ablates the arousal response to hypoxia and hypercarbia. Neurosci. 2013 Sep 8. pii: S0306-4522(13)00755-0. doi: 10.1016/j.neuroscience.2013.08.059. PMID24021919
23. Viemari JC, AJ Garcia 3rd*, A Doi*, FE Elsen, G Elsen, JM Ramirez. (2013) Beta-noradrenergic modulation of fictive sighs but not fictive eupneic activity in the isolated respiratory network. Front. Neural Circuits. 7:179. doi: 10.3389/fncir.2013.00179. eCollection 2013. PMID24273495
24. Zanella S, A Doi, AJ Garcia 3rd, F Elsen, S Kirsch, JM Ramirez. (2014) Acute intermittent hypoxia alters the neuromodulatory response of the respiratory network. J. Neurosci. 34:36-50. doi:10.1523/JNEUROSCI.3644-12.2014. PMID24381266
25. Raghuraman S*, Garcia AJ*, TM Anderson, VD Twede, KJ Curticea, K Chase, JM Ramirez, BM Olivera, RW. Teichert. (2014) Defining modulatory inputs into CNS neuronal subclasses by functional pharmacological profiling. Proc Natl Acad Sci 111: 6449-54. doi: 10.1073/pnas.1404421111. Epub 2014 Apr 14. PMID24733934
26. Ramirez JM, Anderson TM, Garcia AJ 3rd. (2014) The ins and outs of breathing. Elife. 17;3:e03375. doi: 10.7554/eLife.03375. PMID24940002
27. Koch H, Caughie C, Elsen FP, Doi A, Garcia AJ 3rd, Zanella S, Ramirez JM. (2015) Prostaglandin E2 differentially modulates the central control of eupnoea, sighs and gasping in mice. J Physiol. 593: 305-19. doi: 10.1113/jphysiol.2014.279794. PMID25281732
28. AJ Garcia 3rd*, S Zanella*, T Dashevskiy 1 , SA Khan, MA Khuu, NR Prabhakar and JM Ramirez. (2016) Chronic intermittent hypoxia alters local respiratory circuit function at the level of the preBötzinger complex. Front Neurosci. 10:4. doi: 10.3389/fnins.2016.00004. (2016)
29. TM Anderson*, AJ Garcia 3rd*, NA Baertsch, J Pollak, JC Bloom, AD Wei, KG Rai, , JM Ramirez. (2016) A novel excitatory network for the control of breathing. Nature (In Press)